Hyaluronic Acid Gel Distribution Pattern in Periocular Area With High-Resolution Ultrasound Imaging.

By Dicembre 19, 2017 Gennaio 24th, 2020 No Comments

Alice S. Goh Jocelyne C. Kohn Daniel B. Rootman Joseph L. Lin Robert A. Goldberg

Aesthetic Surgery Journal, Volume 34, Issue 4, 1 May 2014, Pages 510–515

Published: 01 May 2014


High-resolution ultrasound (HRUS) is a useful tool in defining anatomic and dynamic soft tissue relationships in the periocular area. It also allows visualization of hyaluronic acid (HA) gel within the soft tissue.


The authors investigate the difference in the distribution pattern between 2 HA fillers in the periocular tissue using HRUS.


The charts of 10 patients who underwent periocular injection using HA gel filler and were subsequently examined with HRUS were reviewed. Half of the patients (n = 5) were treated with Restylane-L (Medicis Aesthetics, Inc, Scottsdale, Arizona) and the remaining 5 with Belotero Balance (Merz Aesthetics, Inc, San Mateo, California). Ultrasonographic evaluation (Logiq p6; GE Healthcare, Waukesha, Washington) was performed before and immediately after HA filler injection.


The HA appears as a hypoechoic image within the soft tissue plane on HRUS. Restylane-L filler formed a localized hypoechoic image within the tissue, with some spread into bubbles or pearl-like configuration. Belotero Balance spread more widely into the tissue plane and diffused into an elongated or spindle-shaped hypoechoic image.


Our preliminary data suggest that HA gel fillers with differing production technologies show distinct spread and distribution patterns in the periocular tissues on HRUS examination.